Publications

Full PubMed list of S. McKinnie's publications

41) Integrated metabolomic and genomic insights into amino acid incorporation within the hybrid polyketide-alkaloid antibiotic TLN-05220

J. L. Cordoza*, R. A. Johnson*, A. E. Whiteley, C. A. Horta, J. C. Nicholas, D. M. Owen, L. Rodriguez-Velandia, G. T. Luu, V. Z. Petukhova, J. T. Calhoun, L. M. Sanchez^, S. M. K. McKinnie^, K. R. Watts^

(*authors contributed equally, ^co-corresponding authors)

submitted, 2025, bioRxiv: 10.1101/2025.10.30.685158

40) CURE-ating the substrate scope and functional residues of nonheme iron(II) alpha-ketoglutarate dependent hydroxylase BesE

A. R. Hopiavuori, B. S. Andre*, E. D. Avalos*, S. L. Beal*, G. R. Beck*, C. J. Choi*, E. M. Dolzhansky*, M. X. Du*, I. S. Gallardo*, C. J. Ghorbani*, K. M. Hinaga*, A. T. Nguyen*, S. M. K. McKinnie

(*authors contributed equally)

submitted, 2025, bioRxiv: 10.1101/2025.10.10.681649

39) A high-throughput biocatalytic platform for screening isomeric kainoid natural products

R. A. Shepherd*, M. Ramachandra*, A. R. Hopiavuori, M. C. Jones, C. A. Fihn, A. J. Tabag, A. Manjunath, L. Y. Gad, C. R. Whipple, S. M. K. McKinnie^, L. M. Sanchez^

(*authors contributed equally, ^co-corresponding authors)

submitted, 2025, bioRxiv: 10.1101/2025.09.07.674781

38) Separation of halide oxidation and substrate halogenation chemistries rationalizes site-selective vanadium dependent haloperoxidase catalysis

J. T. Baumgartner, L. A. Varga, J. T. Calhoun, V. H. Balasco Serrão, S. Loerch^, S. M. K. McKinnie^
(^co-corresponding authors)

submitted, 2025, bioRxiv: doi: 10.1101/2025.10.24/684477

37) IDBac: an open-access web platform and compendium for the identification of bacteria by MALDI-TOF mass spectrometry.

N. K. Krull*, M. Strobel*, J. Saulog, L. Zaroubi, B. S. Paulo, M. Timba, D. R. Braun, G. Mingolelli, J. Raherisoanjato, R. A. Shepherd, A. F. Scott, C. De Silva, C. Fergusson, Z. Daniel, S. K. Pokharel, S. Romanowski, A. Hernandez, M. Monge-Loría, C. E. Dylla, M. M. Natu, V. Z. Petukhova, N. Garg, P. R. Jensen, A. Blachowicz, C. D. Cassilly, L. Guan, D. C. Stevens, J. M. Winter, S. M. K. McKinnie, B. I. Adaikpoh, S. Carlson, E. P. McCauley, W. W. Metcalf, T. S. Bugni, M. W. Mullowney, E. G. Pamer, M. T. Henke, H. Barton, D. O. Carter, A. S. Eustáquio, R. G. Linington, L. M. Sanchez^, M. Wang^, B. T. Murphy^

(*authors contributed equally, ^co-corresponding authors)

submitted, 2025, bioRxiv: doi: 10.1101/2025.10.15.682631

36) 'Need for speed: high throughput' - mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes

R. A. Shepherd, C. A. Fihn, A. J. Tabag, S. M. K. McKinnie, L. M. Sanchez

Nat. Prod. Rep., 2025, 42, 1037-1054.

35) Vanadium-dependent haloperoxidases from diverse microbes halogenate exogenous alkyl quinolone quorum sensing signals

J. T. Baumgartner, C. S. McCaughey, H. S. Fleming, A. R. Lentz, L. M. Sanchez, S. M. K. McKinnie

2024, bioRxiv: doi: 10.1101/2024.07.31.606109

34) Regioselective halogenation of lavanducyanin by a site-selective vanadium-dependent chloroperoxidase

J. T. Baumgartner, S. M. K. McKinnie

Org. Lett., 2024, 26, 5725-5730.

33) Expression, purification, and biochemical characterization of micro- and macroalgal kainoid synthases

A. R. Hopiavuori*, R. T. Huffman*, S. M. K. McKinnie

(*authors contributed equally)

Methods Enzymol., 2024, 704, 233-258.

32) Vanadium haloperoxidases as noncanonical terpene synthases

J. T. Baumgartner*, L. I. Lozano Salazar*, L. A. Varga, G. H. Lefebre, S. M. K. McKinnie

(*authors contributed equally)

Methods Enzymol., 2024, 699, 447-475.

31) Algal kainoid synthases exhibit substrate-dependent hydroxylation and cyclization activities

A. R. Hopiavuori, S. M. K. McKinnie

ACS Chem. Biol., 2023,18, 2457-2463.

30) Mechanistic and structural insights into a divergent PLP-dependent L-enduracididine cyclase from a toxic cyanobacterium

J. L. Cordoza, P. Y.-T. Chen, L. R. Blaustein, S. T. Lima, M. F. Fiore, J. R. Chekan, B. S. Moore, S. M. K. McKinnie

ACS Catal., 2023, 13, 9817-9828.

29) Biosynthesis of guanitoxin enables global environmental detection in freshwater cyanobacteria

S. T. Lima, T. R. Fallon*, J. L. Cordoza*, J. R. Chekan, E. Delbaje, A. R. Hopiavuori, D. O. Alvarenga, S. M. Wood, H. Luhavaya, J. T. Baumgartner, F. A. Dörr, A. Etchegaray, E. Pinto, S. M. K. McKinnie^, M. F. Fiore^, B. S. Moore^.

(*authors contributed equally, ^co-corresponding authors)

J. Am. Chem. Soc., 2022, 114, 9372-9379.

28) Investigating the role of vanadium-dependent haloperoxidase enzymology in microbial secondary metabolism and chemical ecology

J. T. Baumgartner, S. M. K. McKinnie.

mSystems, 2021, 6, e00780-21.

27) Tityus serrulatus scorpion venom as a potential drug source for Chagas' disease: trypanocidal and immunomodulatory activity

P. M. O. Pimentel, D. R. R. de Assis, M. Gualdrón-Lopez, A. Barroso, F. Brant, P. G. Leite, B. C. L. Oliveira, L. Esper, S. M. K. McKinnie, J. C. Vederas, M. N. Cordeiro, P. V. M. dos Reis, M. M. Teixeira, A. M. C. Pimenta, M. H. Borges, M. E. de Lima, F. S. Machado

Clin. Immunol., 2021, 226, 108713.

26) Meroterpenoid natural products from Streptomyces bacteria - the evolution of chemoenzymatic syntheses

L. A. M. Murray, S. M. K. McKinnie, B. S. Moore, J. H. George.

Nat. Prod. Rep., 2020, 37, 1334-1366.

25) Moving pieces in a cellular puzzle: A cryptic peptide from the scorpion toxin Ts14 activates AKT and ERK signaling and decreases cardiac myocyte contractility via dephosphorylation of phospholamban

D. P. Goméz-Mendoza, R. P. Lemos, I. C. G. Jesus, V. Gorshkov, S. M. K. McKinnie, J. C. Vederas, F. Kjeldsen, S. Guatimosim, R. A. Santos, A. M. C. Pimenta, T. Verano-Braga.

J. Proteome Res., 2020, 19, 3467-3477.

24) Comparative genomics and metabolomics in the genus Nocardia

D. Männle, S. M. K. McKinnie, S. S. Mantri, K. Steinke, Z. Lu, B. S. Moore, N. Ziemert, L. Kaysser.

mSystems, 2020, 5, e00125-20.

23) Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into an N-prenyltransferase

J. R. Chekan, S. M. K. McKinnie, J. P. Noel, B. S. Moore.

Proc. Natl. Acad. Sci. U. S. A., 2020, 117, 12799-12805.

22) Nonlinear biosynthetic assembly of alpiniamide by a hybrid cis/trans-AT PKS-NRPS

R. Sigrist, H. Luhavaya, S. M. K. McKinnie, A. F. da Silva, I. D. Jurberg, B. S. Moore, L. G. de Oliveira.

ACS Chem. Biol., 2020, 15, 1067-1077.

21) Guanitoxin, re-naming a cyanobacterial organophosphate toxin

M. F. Fiore, S. T. de Lima, W. W. Carmichael, S. M. K. McKinnie, J. R. Chekan, B. S. Moore.

Harmful Algae, 2020, 92, 101737.

Publications before UCSC

20) Cariogenic Streptococcus mutans produces tetramic acid strain-specific antibiotics that impair commensal colonization

X. Tang, Y. Kudo, J. L. Baker, S. LaBonte, P. A. Jordan, S. M. K. McKinnie, J. Guo, T. Huan, B. S. Moore, and A. Edlund.

ACS Infect. Dis., 2020, 6, 563-571.

19) Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage

Z.-R. Li, J. Li, W. Cai, J. Y. H. Lai, S. M. K. McKinnie, W.-P. Zhang, B. S. Moore, W. Zhang, and P.-Y. Qian.

Nat. Chem., 2019, 11, 880-889.

18) Scalable biosynthesis of the seaweed neurochemical kainic acid.

J. R. Chekan, S. M. K. McKinnie, M. L. Moore, S. G. Poplawski, T. P. Michael, and B. S. Moore.

Angew. Chem. Int. Ed., 2019, 58, 8454-8457.

17) Biosynthesis of L-4-chlorokynurenine, a lipopeptide antibiotic non-proteinogenic amino acid and antidepressant prodrug.

H. L. Luhavaya, R. Sigrist, J. R. Chekan, S. M. K. McKinnie, and B. S. Moore.

Angew. Chem. Int. Ed., 2019, 58, 8394-8399.

16) Synthesis, bioactivity and enzymatic modification of a focused compound library of thiotetromycin C-5 derivatives.

M. L. Rothe, J. Li, E. Garibay, B. S. Moore*, and S. M. K. McKinnie*.

(*co-corresponding authors)

Org. Biomol. Chem., 2019, 17, 3416-3423.

15) Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents.

C. Fischer, T. Lamer, W. Wang, S. M. K. McKinnie, X. Iturrioz, C. Llorens-Cortes, G. Y. Oudit, and J. C. Vederas.

Eur. J. Med. Chem., 2019, 166, 119-124.

14) Total enzyme syntheses of napyradiomycins A1 and B1.

S. M. K. McKinnie*, Z. D. Miles*, P. A. Jordan, T. Awakawa, H. P. Pepper, L. A. M. Murray, J. H. George, and B. S. Moore.

(*authors contributed equally)

J. Am. Chem. Soc., 2018, 140, 17840-17845.

13) Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom.

J. K. Brunson*, S. M. K. McKinnie*, J. R. Chekan, J. P. McCrow, Z. D. Miles, E. M. Bertrand, V. A. Bielinski, H. Luhavaya, M. Oborník, G. J. Smith, D. A. Hutchins, A. E. Allen, and B. S. Moore. (*authors contributed equally)

Science, 2018, 361, 1356-1358.

12) Total synthesis establishes the biosynthetic pathway to the naphterpin and marinone natural products.

L. A. M. Murray, S. M. K. McKinnie, H. P. Pepper, R. Erni, Z. D. Miles, M. C. Cruickshank, B. López-Pérez, B. S. Moore, and J. H. George.

Angew. Chem. Int. Ed. Engl., 2018, 57, 11009-11014.

11) Characterization and biochemical assays of Streptomyces vanadium-dependent chloroperoxidases.

S. M. K. McKinnie, Z. D. Miles, and B. S. Moore.

Methods Enzymol., 2018, 604, 405-424.

10) Organohalogens naturally biosynthesized in marine environments and produced as disinfection byproducts alter sarco/endoplasmic reticulum Ca2+ dynamics.

J. Zheng, S. M. K. McKinnie, A. E. El Gamal, W. Feng, Y. Dong, V. Agarwal, W. Fenical, A. Kumar, Z. Cao, B. S. Moore, and I. N. Pessah.

Environ. Sci. Technol., 2018, 52, 5469-5478.

9) Synthetic modification within the “RPRL” region of apelin peptides: Impact on cardiovascular activity and stability to neprilysin and plasma degradation.

S. M. K. McKinnie, W. Wang, C. Fischer, T. McDonald, K. R. Kalin, X. Iturrioz, C. Llorens-Cortes, G. Y. Oudit, and J. C. Vederas.

J. Med. Chem., 2017, 60, 6408-6427.

8) Targeting the apelin pathway as a novel therapeutic approach for cardiovascular disease.

J.-C. Zhong, Z.-Z. Zhang, W. Wang, S. M. K. McKinnie, J. C. Vederas, and G. Y. Oudit.

Biochem. Biophys. Acta, Mol. Basis Dis., 2017, 1863, 1942-1950.

7) The metalloprotease neprilysin degrades and inactivates apelin peptides.

S. M. K. McKinnie, C. Fischer, K. M. H. Tran, W. Wang, F. Mosquera, G. Y. Oudit, and J. C. Vederas.

ChemBioChem., 2016, 17, 1495-1498.

6) Angiotensin converting enzyme 2 metabolizes and partially inactivates pyr-apelin-13 and apelin-17: Physiological effects in the cardiovascular system.

W. Wang, S. M. K. McKinnie, M. Farhan, M. Paul, T. McDonald, B. McLean, C. Llorens-Cortes, S. Hazra, A. G. Murray, J. C. Vederas, and G. Y. Oudit.

Hypertension, 2016, 68, 365-377.

5) Differential response of orthologous L,L-diaminopimelate aminotransferases (DapL) to enzyme inhibitory antibiotic lead compounds.

S. M. K. McKinnie, E. M. Rodriguez-Lopez, J. C. Vederas, J. M. Crowther, H. Suzuki, R. C. J. Dobson, T. Leustek, A. J. Triassi, M. S. Wheatley, and A. O. Hudson.

Bioorg. Med. Chem., 2014, 22, 523-530.

4) Loss of apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: Therapeutic potential of synthetic apelin analogues.

W. Wang, S. M. K. McKinnie, V. B. Patel, G. Haddad, Z. Wang, P. Zhabyeyev, S. K. Das, R. Basu, B. McLean, V. Kandalam, J. M. Penninger, Z. Kassiri, J. C. Vederas, A. G. Murray, and G. Y. Oudit.

J. Am. Heart Assoc., 2013, 2, e000249.

3) The solid phase supported peptide synthesis of analogues of the lantibiotic lactocin S.

S. M. K. McKinnie, A. C. Ross, M. J. Little, and J. C. Vederas.

MedChemComm, 2012, 3, 971-975.

2) The synthesis of active and stable diaminopimelate analogues of the lantibiotic peptide lactocin S.

A. C. Ross, S. M. K. McKinnie, and J. C. Vederas.

J. Am. Chem. Soc., 2012, 134, 2008-2011.

1) Solid supported synthesis and biological evaluation of the lantibiotic peptide, bis-desmethyl lacticin 3147 A2.

V. R. Pattabiraman, S. M. K. McKinnie, and J. C. Vederas.

Angew. Chem. Int. Ed., 2008, 47, 9472-9475.